Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients

• C. Felice,
• A. Lewis,
• S. Iqbal,
• H. Gordon,
• A. Rigoni,
• M.P. Colombo,
• A. Armuzzi,
• R. Feakins,
• J.O. Lindsay,
• A. Silver

Affiliations

C. Felice

Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom; Department of Internal Medicine, University of Padua, Internal Medicine 1 Unit, Ca’ Foncello Hospital, Treviso, Italy

A. Lewis

Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom

S. Iqbal

Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom

H. Gordon

Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom

A. Rigoni

Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

M.P. Colombo

Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

A. Armuzzi

IBD Unit, Gemelli Hospital Foundation-Catholic University, Rome, Italy

R. Feakins

Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, United Kingdom

J.O. Lindsay

Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom

A. Silver

Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London, United Kingdom; Correspondence Address correspondence to: Andrew Silver, PhD, FRCPath, Blizard Institute, 4 Newark Street, London E1 2AT, United Kingdom. fax: +44(0)208 882 2200.