World Journal of Emergency Surgery (May 2012)

Complicated intra-abdominal infections in Europe: preliminary data from the first three months of the CIAO Study

  • Sartelli Massimo,
  • Catena Fausto,
  • Ansaloni Luca,
  • Leppaniemi Ari,
  • Taviloglu Korhan,
  • van Goor Harry,
  • Viale Pierluigi,
  • Lazzareschi Daniel,
  • de Werra Carlo,
  • Marrelli Daniele,
  • Colizza Sergio,
  • Scibé Rodolfo,
  • Alis Halil,
  • Torer Nurkan,
  • Navarro Salvador,
  • Catani Marco,
  • Kauhanen Saila,
  • Augustin Goran,
  • Sakakushev Boris,
  • Massalou Damien,
  • Pletinckx Pieter,
  • Kenig Jakub,
  • Di Saverio Salomone,
  • Guercioni Gianluca,
  • Rausei Stefano,
  • Laine Samipetteri,
  • Major Piotr,
  • Skrovina Matej,
  • Angst Eliane,
  • Pittet Olivier,
  • Gerych Ihor,
  • Tepp Jaan,
  • Weiss Guenter,
  • Vasquez Giorgio,
  • Vladov Nikola,
  • Tranà Cristian,
  • Vettoretto Nereo,
  • Delibegovic Samir,
  • Dziki Adam,
  • Giraudo Giorgio,
  • Pereira Jorge,
  • Poiasina Elia,
  • Tzerbinis Helen,
  • Hutan Martin,
  • Vereczkei Andras,
  • Krasniqi Avdyl,
  • Seretis Charalampos,
  • Diaz-Nieto Rafael,
  • Mesina Cristian,
  • Rems Miran,
  • Campanile Fabio,
  • Agresta Ferdinando,
  • Coletta Pietro,
  • Uotila-Nieminen Mirjami,
  • Dente Mario,
  • Bouliaris Konstantinos,
  • Lasithiotakis Konstantinos,
  • Khokha Vladimir,
  • Zivanović Dragoljub,
  • Smirnov Dmitry,
  • Marinis Athanasios,
  • Negoi Ionut,
  • Ney Ludwig,
  • Bini Roberto,
  • Leon Miguel,
  • Aloia Sergio,
  • Huchon Cyrille,
  • Moldovanu Radu,
  • de Melo Renato,
  • Giakoustidis Dimitrios,
  • Ioannidis Orestis,
  • Cucchi Michele,
  • Pintar Tadeja,
  • Jovine Elio

DOI
https://doi.org/10.1186/1749-7922-7-15
Journal volume & issue
Vol. 7, no. 1
p. 15

Abstract

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Abstract The CIAO Study is a multicenter observational study currently underway in 66 European medical institutions over the course of a six-month study period (January-June 2012). This preliminary report overviews the findings of the first half of the study, which includes all data from the first three months of the six-month study period. Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 912 patients with a mean age of 54.4 years (range 4–98) were enrolled in the study during the first three-month period. 47.7% of the patients were women and 52.3% were men. Among these patients, 83.3% were affected by community-acquired IAIs while the remaining 16.7% presented with healthcare-associated infections. Intraperitoneal specimens were collected from 64.2% of the enrolled patients, and from these samples, 825 microorganisms were collectively identified. The overall mortality rate was 6.4% (58/912). According to univariate statistical analysis of the data, critical clinical condition of the patient upon hospital admission (defined by severe sepsis and septic shock) as well as healthcare-associated infections, non-appendicular origin, generalized peritonitis, and serious comorbidities such as malignancy and severe cardiovascular disease were all significant risk factors for patient mortality. White Blood Cell counts (WBCs) greater than 12,000 or less than 4,000 and core body temperatures exceeding 38°C or less than 36°C by the third post-operative day were statistically significant indicators of patient mortality.