Nature Communications (Jun 2021)
SARS-CoV-2 infection and transmission in the North American deer mouse
- Bryan D. Griffin,
- Mable Chan,
- Nikesh Tailor,
- Emelissa J. Mendoza,
- Anders Leung,
- Bryce M. Warner,
- Ana T. Duggan,
- Estella Moffat,
- Shihua He,
- Lauren Garnett,
- Kaylie N. Tran,
- Logan Banadyga,
- Alixandra Albietz,
- Kevin Tierney,
- Jonathan Audet,
- Alexander Bello,
- Robert Vendramelli,
- Amrit S. Boese,
- Lisa Fernando,
- L. Robbin Lindsay,
- Claire M. Jardine,
- Heidi Wood,
- Guillaume Poliquin,
- James E. Strong,
- Michael Drebot,
- David Safronetz,
- Carissa Embury-Hyatt,
- Darwyn Kobasa
Affiliations
- Bryan D. Griffin
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Mable Chan
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Nikesh Tailor
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Emelissa J. Mendoza
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Anders Leung
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Bryce M. Warner
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Ana T. Duggan
- Science Technology Cores and Services, National Microbiology Laboratory, Public Health Agency of Canada
- Estella Moffat
- National Centre for Foreign Animal Disease, Canadian Food Inspection Agency
- Shihua He
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Lauren Garnett
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Kaylie N. Tran
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Logan Banadyga
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Alixandra Albietz
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Kevin Tierney
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Jonathan Audet
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Alexander Bello
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Robert Vendramelli
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Amrit S. Boese
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Lisa Fernando
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- L. Robbin Lindsay
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Claire M. Jardine
- Department of Pathobiology, Canadian Wildlife Health Cooperative, Department of Pathobiology, University of Guelph
- Heidi Wood
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Guillaume Poliquin
- Department of Medical Microbiology and Infectious Diseases, College of Medicine, Faculty of Health Sciences, University of Manitoba
- James E. Strong
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Michael Drebot
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- David Safronetz
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- Carissa Embury-Hyatt
- National Centre for Foreign Animal Disease, Canadian Food Inspection Agency
- Darwyn Kobasa
- Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada
- DOI
- https://doi.org/10.1038/s41467-021-23848-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Deer mice are natural hosts for a number of human pathogens. Here, Griffin et al. report that intranasal exposure of the North American deer mouse to SARS-CoV-2 results in virus replication and shedding, despite causing only mild or asymptomatic illness. Additionally, infected deer mice can transmit SARS-CoV-2 to naïve deer mice.
