Cancer Management and Research (2020-10-01)

A Study of Prognostic Factors of Chinese Patients with Gynecologic Tract Carcinosarcomas Prognosis of Gynecologic Carcinosarcomas

  • Ye D,
  • Shen HR,
  • Yao L

Journal volume & issue
Vol. Volume 12
pp. 10781 – 10788

Abstract

Read online

Dan Ye, Hao-Ran Shen, Liangqing Yao Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People’s Republic of ChinaCorrespondence: Liangqing YaoObstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People’s Republic of ChinaTel/Fax +86-021-33189900Email [email protected]: Thinking of the rarity and malignancy of gynecologic tract carcinosarcomas (GTCS), the aim of the study was to investigate the possible predictors of relapse-free survival (RFS) and overall survival (OS) for GTCS patients.Methods: We performed a retrospective cohort study of women with GTCS at our hospital between January 2009 and December 2013. We used the Kaplan–Meier method to calculate RFS and OS, and Cox regression analysis to define the survival effects of risk factors.Results: A total of 45 GTCS patients were included in the study. The median follow-up time was 46 months. Cox regression analysis showed that lymph node metastasis was significantly associated with worse RFS (HR: 3.145; 95%CI: 1.181– 8.378; P=0.022) and OS (HR: 4.065; 95%CI: 1.57– 10.524; P=0.004). Pelvic lymphadenectomy had a favorable RFS (HR: 0.213; 95%CI: 0.057– 0.796; P= 0.021).Conclusion: Lymph node metastasis significantly affected the prognosis of uterine carcinosarcoma. Pelvic lymphadenectomy could reduce the relapse rate of GTCS patients.Keywords: pelvic lymphadenectomy, relapse-free survival, overall survival, gynecologic tract carcinosarcomas

Keywords