High-Sensitivity SPR Sensor Based on the Theory of the Solution of Inventive Problems

Abstract

Fiber SPR biosensors have low sensitivity and accuracy in detecting biomolecules. In this study, the TRIZ is applied to molecules and optimization. By defining the prototype system, clarifying the components and interacting objects, and adopting a functional model analysis and causal analysis, we deeply explored the key points and root causes of leakage and used a variety of tools, such as technological contradiction, object-field analysis, the HOW-TO model and knowledge effect library, physical contradiction, and the villain method, to come up with different solutions. A novel multimode–single-mode–multimode fiber SPR sensor based on the structure of gold (Au)–molybdenum disulfide (MoS2)–gold nanoparticles was designed and manufactured by using the TRIZ systematically for the first time. Under the effective guidance of the TRIZ, the sensitivity of the novel sensor is significantly enhanced after the optimization and experimental verification. The new sensor provides an effective reduction in the cost of detection and production and at the same time has excellent stability, ease of preparation, and high reproducibility, which is of significant value and significance for practical applications.

Keywords

• surface plasmon resonance
• fiber sensor
• sensitivity enhancement
• TRIZ theory