Iranian Journal of Public Health (Aug 2007)

Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats

  • SH Fakher,
  • M Djalali,
  • SMB Tabei,
  • H Zeraati,
  • E Javadi,
  • MR Sadeghi,
  • E Mostafavi,
  • F Fatehi

Journal volume & issue
Vol. 36, no. 2
pp. 58 – 63

Abstract

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Background: To assess the effect of supplementation with vitamins A, E and C and &#969;-3 fatty acids on lipid peroxidation in strepto¬zotocin (STZ) induced diabetic rats. Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia¬betic with vitamin A, E as well as C supplementation and diabetic with &#969;-3 fatty acids supplementation. After four weeks of treat¬ment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart ho¬mogenate. Results: In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P< 0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P< 0.05). A signifi¬cant decrease in heart MDA (P< 0.05) was observed in diabetic rats with &#969;-3 fatty acids supplementation. Conclusion: Supplementation of vitamin A, E and C and &#969;-3 fatty acids was found to decrease lipid peroxidation to some ex¬tent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.

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