Nature Communications (May 2022)
TH17 cells promote CNS inflammation by sensing danger signals via Mincle
- Quanri Zhang,
- Weiwei Liu,
- Han Wang,
- Hao Zhou,
- Katarzyna Bulek,
- Xing Chen,
- Cun-Jin Zhang,
- Junjie Zhao,
- Renliang Zhang,
- Caini Liu,
- Zizhen Kang,
- Robert A. Bermel,
- George Dubyak,
- Derek W. Abbott,
- Tsan Sam Xiao,
- Laura E. Nagy,
- Xiaoxia Li
Affiliations
- Quanri Zhang
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Weiwei Liu
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Han Wang
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Hao Zhou
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Katarzyna Bulek
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Xing Chen
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Cun-Jin Zhang
- Department of Neurology, Nanjing Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
- Junjie Zhao
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Renliang Zhang
- Proteomics and Metabolomics Core, Department of Research Core Services, Lerner Research Institute
- Caini Liu
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Zizhen Kang
- Department of Pathology, University of Iowa
- Robert A. Bermel
- Mellen Center for Multiple Sclerosis, Cleveland Clinic
- George Dubyak
- Department of Physiology and Biophysics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine
- Derek W. Abbott
- Department of Pathology, Case Western Reserve University
- Tsan Sam Xiao
- Department of Pathology, Case Western Reserve University
- Laura E. Nagy
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- Xiaoxia Li
- Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-30174-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Mincle is a pattern recognition receptor that senses danger signals in innate immune cells. Here authors show in an experimental autoimmune encephalomyelitis mouse model that tissue damage triggers Mincle signaling on inflammatory helper T cells, leading to inflammasome-mediated IL-1β production and reinforced inflammation.
