Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease

Abstract

Liucan Wang, Min Yu, Hua Yang Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Min Yu; Hua Yang Tel/Fax [phone]Email [email protected]; [email protected]: The effective colon drug delivery remains to be an international frontier research in inflammatory bowel disease (IBD) therapy. The exploration and research of nanocarrier-based nanomedicine with great potential brings new opportunities for IBD therapy and diagnoses. Functional nanocarriers with varying morphology and characteristics can not only effectively avoid the destruction of the complex gastrointestinal (GI) tract microenvironment but also endow drugs with target therapy and improved bioavailability, thus elevating therapeutic efficacy. In this review, we illustrated several challenges in IBD therapy, then emphasis on some latest research progress of nanoparticles based therapy of oral administration, rectal administration and parenteral administration, as well as IBD diagnoses. Finally, we described the future perspective of nanocarriers in the treatment and diagnoses of IBD.Keywords: inflammatory bowel disease, gastrointestinal tract microenvironment, drug delivery system, precise therapy, diagnose

Keywords

• inflammatory bowel disease
• gastrointestinal tract microenvironment
• drug delivery syatems
• precise therapy
• diagnose