ZnO nanotube waveguide arrays on graphene films for local optical excitation
on biological cells
Hyeonjun Baek,
Hankyul Kwak,
Minho S. Song,
Go Eun Ha,
Jongwoo Park,
Youngbin Tchoe,
Jerome K. Hyun,
Hye Yoon Park,
Eunji Cheong,
Gyu-Chul Yi
Affiliations
Hyeonjun Baek
Department of Physics and Astronomy, Institute of Applied
Physics (IAP), Research Institute of Advanced Materials (RIAM), Seoul
National University, Seoul 08826, South Korea
Hankyul Kwak
Department of Biotechnology, College of Life Science and
Biotechnology, Yonsei University, Seoul 120-749, South
Korea
Minho S. Song
Department of Physics and Astronomy, Institute of Applied
Physics (IAP), Research Institute of Advanced Materials (RIAM), Seoul
National University, Seoul 08826, South Korea
Go Eun Ha
Department of Biotechnology, College of Life Science and
Biotechnology, Yonsei University, Seoul 120-749, South
Korea
Jongwoo Park
Department of Physics and Astronomy, Institute of Applied
Physics (IAP), Research Institute of Advanced Materials (RIAM), Seoul
National University, Seoul 08826, South Korea
Youngbin Tchoe
Department of Physics and Astronomy, Institute of Applied
Physics (IAP), Research Institute of Advanced Materials (RIAM), Seoul
National University, Seoul 08826, South Korea
Jerome K. Hyun
Department of Chemistry and Nanoscience, Ewha
Womans University, Seoul 120-750, South Korea
Hye Yoon Park
Department of Physics and Astronomy, Seoul
National University, Seoul 08826, South Korea
Eunji Cheong
Department of Biotechnology, College of Life Science and
Biotechnology, Yonsei University, Seoul 120-749, South
Korea
Gyu-Chul Yi
Department of Physics and Astronomy, Institute of Applied
Physics (IAP), Research Institute of Advanced Materials (RIAM), Seoul
National University, Seoul 08826, South Korea
We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical excitation. For the waveguide fabrication, position-controlled and well-ordered ZnO nanotube arrays were grown on chemical vapor deposited graphene films with a submicron patterned mask layer and Au prepared between the interspace of nanotubes. Mammalian cells were cultured on the nanotube waveguide arrays and were locally excited by light illuminated through the nanotubes. Fluorescence and optogenetic signals could be excited through the optical nanoprobes. This method offers the ability to investigate cellular behavior with a high spatial resolution that surpasses the current limitation.
