IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS

Abstract

In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNFα, IL-1β, IL-10, as well as autoantibodies to collagen I and III type have been studied. It was established that the hyperproduction of T lymphocytes mainly Th2 link (increased relative to the Trel content of 17.4% of the Tabs — 30.4%, IL-1β — 32.6%, IL-10 — 43.5%) arises because of the decrease in the phagocytic activity of the cells (ratio of active phagocytes 1.98±1.07 at a rate of 2.5–2.9; percentage phagocytosis 56.35±13.89% at a rate of 65–95%). The increase in the content of B-lymphocytes (Brel — 84.8%, in the Babs — 43.5%) and circulating immune complexes, in some cases combined with decreased levels of immunoglobulins G, A, M, believe, intended to compensate the negative impact of Mycobacterium tuberculosis the body of the patient. The larger the specific process, the more intense the metabolism of connective tissue, stimulates the formation of type-specific autoantibodies involved in the elimination of connective tissue components. Detecting increased levels of autoantibodies to collagen type I — 50% and type III — 26.1%, probably due to the fact that in the initial stage of development of pulmonary tuberculosis «pulmonary collagen» is involved in the pathological process is less than I type.

Keywords

• tuberculosis
• tnfα
• il-1β
• il-10
• type i collagen
• type iii collagen
• autoantibodies