Nature Communications (May 2022)
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
- Livia V. Patrono,
- Bram Vrancken,
- Matthias Budt,
- Ariane Düx,
- Sebastian Lequime,
- Sengül Boral,
- M. Thomas P. Gilbert,
- Jan F. Gogarten,
- Luisa Hoffmann,
- David Horst,
- Kevin Merkel,
- David Morens,
- Baptiste Prepoint,
- Jasmin Schlotterbeck,
- Verena J. Schuenemann,
- Marc A. Suchard,
- Jeffery K. Taubenberger,
- Luisa Tenkhoff,
- Christian Urban,
- Navena Widulin,
- Eduard Winter,
- Michael Worobey,
- Thomas Schnalke,
- Thorsten Wolff,
- Philippe Lemey,
- Sébastien Calvignac-Spencer
Affiliations
- Livia V. Patrono
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- Bram Vrancken
- Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Matthias Budt
- Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute
- Ariane Düx
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- Sebastian Lequime
- Cluster of Microbial Ecology, Groningen Institute for Evolutionary Life Sciences, University of Groningen
- Sengül Boral
- Institute for Pathology
- M. Thomas P. Gilbert
- Center for Evolutionary Hologenomics, The GLOBE Institute, University of Copenhagen
- Jan F. Gogarten
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- Luisa Hoffmann
- Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute
- David Horst
- Institute for Pathology
- Kevin Merkel
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- David Morens
- Office of the Director, National Institute of Allergy and Infectious Diseases
- Baptiste Prepoint
- Viral Evolution, Robert Koch Institute
- Jasmin Schlotterbeck
- Viral Evolution, Robert Koch Institute
- Verena J. Schuenemann
- Institute of Evolutionary Medicine, University of Zurich
- Marc A. Suchard
- Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles
- Jeffery K. Taubenberger
- Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases
- Luisa Tenkhoff
- Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute
- Christian Urban
- Institute of Evolutionary Medicine, University of Zurich
- Navena Widulin
- Berlin Museum of Medical History
- Eduard Winter
- Pathological-anatomical collection in the Narrenturm, Natural History Museum of Vienna
- Michael Worobey
- Department of Ecology and Evolutionary Biology, University of Arizona
- Thomas Schnalke
- Berlin Museum of Medical History
- Thorsten Wolff
- Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute
- Philippe Lemey
- Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Sébastien Calvignac-Spencer
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- DOI
- https://doi.org/10.1038/s41467-022-29614-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
For archival pathogens, like pH1N1 Influenza A virus the causative agent of 1918/19 pandemic, only few whole genome sequences exist. Here, Patrono et al. provide one complete and two partial genomes from Germany and find variation in two sites in the nucleoprotein gene in pandemic samples compared to pre-pandemic samples, that are associated with resistance to host antiviral response, pointing at a possible viral adaptation to humans.
