Lemborexant‐induced interstitial lung disease: A case report

Abstract

Abstract We report the first case of drug‐induced interstitial lung disease attributed to lemborexant. A 66‐year‐old man reported to our hospital with the acute onset of cough and breathlessness with ground‐glass opacity on radiological examination. Symptoms were identified after taking lemborexant for 2 consecutive days. The patient had undergone lemborexant treatment 2 years prior and had exhibited no symptoms at that time. The drug‐induced lymphocyte stimulation test for lemborexant was positive. He showed rapid improvement upon treatment with steroid. With the rise in prescriptions of lemborexant for insomnia, lemborexant should be considered as a possible cause of drug‐induced interstitial lung disease.

Keywords

• drug‐induced interstitial lung disease
• lemborexant
• orexin receptor antagonists
• type IV hypersensitivity reactions