Nature Communications (Apr 2018)
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
- Zhe Li,
- Jiwei Zhang,
- Xinyang Liu,
- Shengli Li,
- Qifeng Wang,
- Di Chen,
- Zhixiang Hu,
- Tao Yu,
- Jie Ding,
- Jinjun Li,
- Ming Yao,
- Jia Fan,
- Shenglin Huang,
- Qiang Gao,
- Yingjun Zhao,
- Xianghuo He
Affiliations
- Zhe Li
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Jiwei Zhang
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Xinyang Liu
- Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan University
- Shengli Li
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Qifeng Wang
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Di Chen
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Zhixiang Hu
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Tao Yu
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Jie Ding
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Jinjun Li
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Ming Yao
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Jia Fan
- Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan University
- Shenglin Huang
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Qiang Gao
- Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan University
- Yingjun Zhao
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- Xianghuo He
- Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan University
- DOI
- https://doi.org/10.1038/s41467-018-04006-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.
