PLoS ONE (Jan 2022)

Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.

  • Kseniya Rubina,
  • Anna Shmakova,
  • Aslan Shabanov,
  • Yulii Andreev,
  • Natalia Borovkova,
  • Vladimir Kulabukhov,
  • Anatoliy Evseev,
  • Konstantin Popugaev,
  • Sergey Petrikov,
  • Ekaterina Semina

DOI
https://doi.org/10.1371/journal.pone.0264072
Journal volume & issue
Vol. 17, no. 2
p. e0264072

Abstract

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COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.