Frontiers in Genetics (Oct 2021)
A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study
- Heidi Marjonen,
- Heidi Marjonen,
- Minttu Marttila,
- Teemu Paajanen,
- Teemu Paajanen,
- Marleena Vornanen,
- Minna Brunfeldt,
- Anni Joensuu,
- Anni Joensuu,
- Otto Halmesvaara,
- Kimmo Aro,
- Mervi Alanne-Kinnunen,
- Pekka Jousilahti,
- Katja Borodulin,
- Katja Borodulin,
- Seppo Koskinen,
- Tiinamaija Tuomi,
- Tiinamaija Tuomi,
- Tiinamaija Tuomi,
- Tiinamaija Tuomi,
- Tiinamaija Tuomi,
- Pirjo Ilanne-Parikka,
- Jaana Lindström,
- Merja K. Laine,
- Merja K. Laine,
- Kirsi Auro,
- Kirsi Auro,
- Helena Kääriäinen,
- Markus Perola,
- Markus Perola,
- Kati Kristiansson,
- Kati Kristiansson
Affiliations
- Heidi Marjonen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Heidi Marjonen
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- Minttu Marttila
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Teemu Paajanen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Teemu Paajanen
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- Marleena Vornanen
- Department of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland
- Minna Brunfeldt
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Anni Joensuu
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Anni Joensuu
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- Otto Halmesvaara
- Department of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland
- Kimmo Aro
- Negen Ltd., Helsinki, Finland
- Mervi Alanne-Kinnunen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Pekka Jousilahti
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Katja Borodulin
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Katja Borodulin
- Age Institute, Helsinki, Finland
- Seppo Koskinen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Tiinamaija Tuomi
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- Tiinamaija Tuomi
- Abdominal Centre, Endocrinology, Helsinki University Hospital, Helsinki, Finland
- Tiinamaija Tuomi
- Folkhälsan Research Centre, Helsinki, Finland
- Tiinamaija Tuomi
- Institute for Molecular Medicine Finland, Helsinki, Finland
- Tiinamaija Tuomi
- Lund University Diabetes Centre, Lund University, Malmö, Sweden
- Pirjo Ilanne-Parikka
- 0Finnish Diabetes Association, Tampere, Finland
- Jaana Lindström
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Merja K. Laine
- Folkhälsan Research Centre, Helsinki, Finland
- Merja K. Laine
- 1Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
- Kirsi Auro
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Kirsi Auro
- Negen Ltd., Helsinki, Finland
- Helena Kääriäinen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Markus Perola
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Markus Perola
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- Kati Kristiansson
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Kati Kristiansson
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
- DOI
- https://doi.org/10.3389/fgene.2021.763159
- Journal volume & issue
-
Vol. 12
Abstract
We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.
Keywords
- web portal
- type 2 diabetes
- coronary heart disease
- venous thromboembolism
- polygenic risk sore
- finhealth 2017 study
