Communications Biology (Mar 2022)
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats
- Kaori Oka,
- Shusuke Fujioka,
- Yoshimi Kawamura,
- Yoshihiro Komohara,
- Takeshi Chujo,
- Koki Sekiguchi,
- Yuki Yamamura,
- Yuki Oiwa,
- Natsuko Omamiuda-Ishikawa,
- Shohei Komaki,
- Yoichi Sutoh,
- Satoko Sakurai,
- Kazuhito Tomizawa,
- Hidemasa Bono,
- Atsushi Shimizu,
- Kimi Araki,
- Takuya Yamamoto,
- Yasuhiro Yamada,
- Hiroyuki Oshiumi,
- Kyoko Miura
Affiliations
- Kaori Oka
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Shusuke Fujioka
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Yoshimi Kawamura
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Yoshihiro Komohara
- Department of Cell Pathology, Faculty of Life Sciences, Kumamoto University
- Takeshi Chujo
- Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
- Koki Sekiguchi
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Yuki Yamamura
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Yuki Oiwa
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Natsuko Omamiuda-Ishikawa
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- Shohei Komaki
- Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University
- Yoichi Sutoh
- Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University
- Satoko Sakurai
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Kazuhito Tomizawa
- Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
- Hidemasa Bono
- Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University
- Atsushi Shimizu
- Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University
- Kimi Araki
- Center for Metabolic Regulation of Healthy Aging, Kumamoto University
- Takuya Yamamoto
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yasuhiro Yamada
- AMED-CREST, AMED
- Hiroyuki Oshiumi
- Department of Immunology, Faculty of Life Sciences, Kumamoto University
- Kyoko Miura
- Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
- DOI
- https://doi.org/10.1038/s42003-022-03241-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Naked mole rats are found to be resistant to cancer development through dampened inflammatory response due to genetically determined impaired necroptosis, with essential necroptosis genes RIPK3 and MLKL containing mutations causing premature stop codons.
