Nature Communications (Mar 2023)

The RNA-binding protein hnRNP F is required for the germinal center B cell response

  • Hengjun Huang,
  • Yuxing Li,
  • Gaopu Zhang,
  • Gui-Xin Ruan,
  • Zhijian Zhu,
  • Wenjing Chen,
  • Jia Zou,
  • Rui Zhang,
  • Jing Wang,
  • Yu Ouyang,
  • Shengli Xu,
  • Xijun Ou

DOI
https://doi.org/10.1038/s41467-023-37308-z
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

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The germinal centre (GC) response is characterized by regulated production of high affinity, class-switched antibodies in response to T-cell dependent antigens. Here authors show that the GC response is not only regulated at the transcriptional and protein levels, but also by the RNA-binding protein hnRNP F via alternative splicing of the co-stimulatory molecule CD40.