Investigation of celiac disease followed by immune thrombocytopenic purpura diagnosis in patients and comparison with literature

Abstract

INTRODUCTION[|]Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) can be seen together because of the similar autoimmune mechanisms. In this study, it was aimed to evaluate the frequency of CD in ITP patients with the literature.[¤]METHODS[|]Twenty nine patients with ITP in Pamukkale University Faculty of Medicine Hospital Pediatric Hematology and Oncology Department was included in the study. Antibodies related to Celiac disease were analysed in patients with ITP. Diagnosis was confirmed by biopsy in patients with positive celiac antibodies. The results were compared with the literature.[¤]RESULTS[|]Thirteen patients (44.8%) were female and 16 (55.2%) were male. The mean age was 7.2+-4.7. The mean platelet count at the time of admission was 13.440+-11.110/mm3 (2.000-41.000). Twelve patients (41.4%) were acute ITP, 6 patients (20.7%) were persistent ITP and 11 patients (37.9%) were chronic ITP according to the duration of thrombocytopenia. Antibody positivity was detected in one of the patients. Histological evaluation was compatible with celiac disease. Results were compared with studies showing prevalence of celiac disease in the population. No significant difference was found.[¤]DISCUSSION AND CONCLUSION[|]Although it is not necessary to perform CD tests in every case with ITP, the presence of differential diagnosis of Celiac disease is important for preventing unnecessary treatment especially in patients with ITP who show growth retardation and malabsortion findings.[¤]

Keywords

• celiac disease
• immune thrombocytopenic purpura
• autoimmunity