CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses

Irmgard U. Haussmann; Yanying Wu; Mohanakarthik P. Nallasivan; Nathan Archer; Zsuzsanna Bodi; Daniel Hebenstreit; Scott Waddell; Rupert Fray; Matthias Soller

doi:10.1038/s41467-022-28549-5

Nature Communications (Mar 2022)

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses

Irmgard U. Haussmann,
Yanying Wu,
Mohanakarthik P. Nallasivan,
Nathan Archer,
Zsuzsanna Bodi,
Daniel Hebenstreit,
Scott Waddell,
Rupert Fray,
Matthias Soller

Affiliations

Irmgard U. Haussmann: School of Biosciences, College of Life and Environmental Sciences, University of Birmingham
Yanying Wu: Centre for Neuronal Circuits and Behaviour, The University of Oxford
Mohanakarthik P. Nallasivan: School of Biosciences, College of Life and Environmental Sciences, University of Birmingham
Nathan Archer: School of Veterinary Medicine and Sciences, University of Nottingham
Zsuzsanna Bodi: School of Biosciences, Plant Science Division, University of Nottingham
Daniel Hebenstreit: School of Life Sciences, University of Warwick
Scott Waddell: Centre for Neuronal Circuits and Behaviour, The University of Oxford
Rupert Fray: School of Biosciences, Plant Science Division, University of Nottingham
Matthias Soller: School of Biosciences, College of Life and Environmental Sciences, University of Birmingham

DOI: https://doi.org/10.1038/s41467-022-28549-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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The two cap methyltransferases (CMTrs) redundantly methylate riboses of first cap adjacent nucleotides in messenger RNAs in Drosophila. Here, CMTrs are required for reward learning and localization of untranslated messenger RNAs to synapses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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