Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking

Divyanshu Mahajan; Hieng Chiong Tie; Bing Chen; Lei Lu

doi:10.1038/s41467-019-11056-5

Nature Communications (Jul 2019)

Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking

Divyanshu Mahajan,
Hieng Chiong Tie,
Bing Chen,
Lei Lu

Affiliations

Divyanshu Mahajan: School of Biological Sciences, Nanyang Technological University
Hieng Chiong Tie: School of Biological Sciences, Nanyang Technological University
Bing Chen: School of Biological Sciences, Nanyang Technological University
Lei Lu: School of Biological Sciences, Nanyang Technological University

DOI: https://doi.org/10.1038/s41467-019-11056-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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Proteins are transported among eukaryotic organelles along the cytoskeleton in membrane carriers. Here authors find that the Dopey1-Mon2 complex functions as a dual-lipid-regulated cargo-adaptor to recruit kinesin-1 to secretory and endocytic organelles or membrane carriers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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