ACUTE RENAL FAILURE DUE TO MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AND TUMORAL CELL INFILTRATION IN A PATIENT WITH MANTLE CELL LYMPHOMA: A CASE REPORT

Abstract

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma that presents in a disseminated state at diagnosis. Multiple extranodal site involvement is frequent, however genitourinary system is rarely affected, being kidneys the most common location. Besides lymphoid cell infiltrations of kidneys, glomerulonephritides are a known disorder associated with non-Hodgkin lymphomas (LNH). Membranoproliferative glomerulonephritis is the most common cause of nephrotic syndrome in these cases. Herein we report a patient who presented acute renal failure, haematuria and subnephrotic range proteinuria due to mebranoproliferative glomerulonephritis and tumoral cell infiltration demonstrated by renal biopsy, in association MCL. Patient´s renal function improved, hematuria and proteinuria resolved after specific lymphoma treatment. Although membranoproliferative glomerulonephritis has been reported to occur in association with non-Hodking´s lymphoma, information concerning the correct treatment of the glomerular disease is limited. Specific lymphoma treatment, unlike the primary forms, constitutes the cornerstone in the management of this glomerular disease, with remission and recurrence that usually runs parallel to the course of the lymphoid malignancy.

Keywords

• Non-Hodgkin lymphoma
• Mantle cell lymphoma
• Proteinuria
• Membranoproliferative glomerulonephritis.