A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa

mBio (Jun 2021)

Affiliations

Nolan Neville: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Nathan Roberge: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Xiang Ji: Risen (Shanghai) Pharma Tech Co., Ltd., Shanghai, China
Preyesh Stephen: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Jiasheng Louis Lu: Risen (Shanghai) Pharma Tech Co., Ltd., Shanghai, China
Zongchao Jia: ORCiD; Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

Abstract

Many priority bacterial pathogens such as P. aeruginosa