Oleuropein and Cancer Chemoprevention: The Link is Hot
Ammad Ahmad Farooqi,
Sundas Fayyaz,
Ana Sanches Silva,
Antoni Sureda,
Seyed Fazel Nabavi,
Andrei Mocan,
Seyed Mohammad Nabavi,
Anupam Bishayee
Affiliations
Ammad Ahmad Farooqi
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan
Sundas Fayyaz
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan
Ana Sanches Silva
Department of Food and Nutrition, National Institute of Health Dr. Ricardo Jorge, I.P., Av. Padre Cruz, 1649-016 Lisbon, Portugal
Antoni Sureda
Research Group on Community Nutrition and Oxidative Stress and CIBEROBN—Physiopathology of Obesity and Nutrition, University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain
Seyed Fazel Nabavi
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran
Andrei Mocan
Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Seyed Mohammad Nabavi
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran
Anupam Bishayee
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA
Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed.
