Surgical Case Reports (Aug 2023)

A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX

  • Misato Araki,
  • Koshi Matsui,
  • Kohji Takagi,
  • Emi Kanaya,
  • Shinichi Sekine,
  • Shiho Nagasawa,
  • Toru Watanabe,
  • Takeshi Miwa,
  • Katsuhisa Hirano,
  • Takamichi Igarashi,
  • Haruyoshi Tanaka,
  • Kazuto Shibuya,
  • Isaya Hashimoto,
  • Shozo Hojo,
  • Isaku Yoshioka,
  • Tomoyuki Okumura,
  • Kenichi Hirabayashi,
  • Tsutomu Fujii

DOI
https://doi.org/10.1186/s40792-023-01719-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 5

Abstract

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Abstract Background Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. Case presentation A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. Conclusions We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.

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