Frontiers in Oncology (Jul 2011)
Sequence variants and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
- Shu-Chun eChuang,
- Shu-Chun eChuang,
- Antonio eAgudo,
- Wolfgang eAhrens,
- Devasena eAnantharaman,
- Simone eBenhamou,
- Stefania eBoccia,
- Stefania eBoccia,
- Chu eChen,
- David eConway,
- Eleonora eFabianova,
- Richard B. Hayes,
- Claire eHealy,
- Ivana eHolcatova,
- Kristina eKjaerheim,
- Pagona eLagiou,
- Philip eLazarus,
- Tatiana V. Macfarlane,
- Manoj eMahimkar,
- Dana eMates,
- Keitaro eMatsuo,
- Franco eMerletti,
- Andres eMetspalu,
- Hal eMorgenstern,
- Joshua eMuscat,
- Gabriella eCadoni,
- Andrew F. Olshan,
- Mark ePurdue,
- Heribert eRamroth,
- Péter eRudnai,
- Stephen M. Schwartz,
- Lorenzo eSimonato,
- Elaine M Smith,
- Erich M. Sturgis,
- Neonila eSzeszenia-Dabrowska,
- Renato eTalamini,
- Peter eThomsom,
- Qingyi eWei,
- David eZaridze,
- Zuo-Feng eZhang,
- Ariana eZnaor,
- Paul eBrennan,
- Paolo eBoffetta,
- Paolo eBoffetta,
- Paolo eBoffetta,
- Mia eHashibe,
- Mia eHashibe
Affiliations
- Shu-Chun eChuang
- Imperial College London
- Shu-Chun eChuang
- International Agency for Research on Cancer
- Antonio eAgudo
- Institut catala d'oncologia (Catalan Institut of Oncology)
- Wolfgang eAhrens
- Bremen Insitute for Prevention Research and Social Medicine (BIPS)
- Devasena eAnantharaman
- Cancer Research Institute
- Simone eBenhamou
- INSERM
- Stefania eBoccia
- Catholic University of Sacred Heart
- Stefania eBoccia
- San Saffaele Pisana
- Chu eChen
- Fred Hutchinson Cancer Research Center (FHCRC)
- David eConway
- University of Glasgow Dental School
- Eleonora eFabianova
- Specialized State Health Institute
- Richard B. Hayes
- New York University
- Claire eHealy
- Trinity College
- Ivana eHolcatova
- First Faculty of Medicine Charles University
- Kristina eKjaerheim
- Cancer Registry of Norway
- Pagona eLagiou
- University of Athens School of Medicine
- Philip eLazarus
- Penn State College of Medicine
- Tatiana V. Macfarlane
- University of Aberdeen
- Manoj eMahimkar
- Cancer Research Institute
- Dana eMates
- Institute of Public Health
- Keitaro eMatsuo
- Aichi Cancer Center Research Institute
- Franco eMerletti
- University of Turin
- Andres eMetspalu
- Estonian Biocenter
- Hal eMorgenstern
- University of Michigan School of Public Health
- Joshua eMuscat
- Penn State College of Medicine
- Gabriella eCadoni
- Università Cattolica del Sacro Cuore
- Andrew F. Olshan
- University of North Carolina
- Mark ePurdue
- National Cancer Institute
- Heribert eRamroth
- University of Heidelberg
- Péter eRudnai
- Fodor József National Center for Public Health
- Stephen M. Schwartz
- Fred Hutchinson Cancer Research Center (FHCRC)
- Lorenzo eSimonato
- University of Padua
- Elaine M Smith
- The University of Iowa College of Public Health
- Erich M. Sturgis
- MD Anderson Cancer Center
- Neonila eSzeszenia-Dabrowska
- The Nofer Institute of Occupational Medicine (NIOM)
- Renato eTalamini
- Aviano Cancer Centre (CRO)
- Peter eThomsom
- Newcastle University
- Qingyi eWei
- MD Anderson Cancer Center
- David eZaridze
- Cancer Research Center
- Zuo-Feng eZhang
- UCLA School of Public Health
- Ariana eZnaor
- Croatian National Institute of Public Health
- Paul eBrennan
- International Agency for Research on Cancer
- Paolo eBoffetta
- Mount Sinai School of Medicine
- Paolo eBoffetta
- International Prevention Research Institute
- Paolo eBoffetta
- International Agency for Research on Cancer
- Mia eHashibe
- University of Utah
- Mia eHashibe
- International Agency for Research on Cancer
- DOI
- https://doi.org/10.3389/fonc.2011.00013
- Journal volume & issue
-
Vol. 1
Abstract
Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms, but there are very few documented associations. In the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR=0.79, 95% CI=0.68-0.93), XRCC1 Arg194Trp rare homozygotes (OR=2.3, 95% CI=1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR=2.7, 95% CI=1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR=1.2, 95% CI=1.1-1.4), and the GSTM1 null genotype (OR=1.1, 95% CI=1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.
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