Nature Communications (Apr 2018)
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
- Akihiko Numata,
- Hui Si Kwok,
- Akira Kawasaki,
- Jia Li,
- Qi-Ling Zhou,
- Jon Kerry,
- Touati Benoukraf,
- Deepak Bararia,
- Feng Li,
- Erica Ballabio,
- Marta Tapia,
- Aniruddha J. Deshpande,
- Robert S. Welner,
- Ruud Delwel,
- Henry Yang,
- Thomas A. Milne,
- Reshma Taneja,
- Daniel G. Tenen
Affiliations
- Akihiko Numata
- Cancer Science Institute of Singapore, National University of Singapore
- Hui Si Kwok
- Cancer Science Institute of Singapore, National University of Singapore
- Akira Kawasaki
- Cancer Science Institute of Singapore, National University of Singapore
- Jia Li
- Cancer Science Institute of Singapore, National University of Singapore
- Qi-Ling Zhou
- Cancer Science Institute of Singapore, National University of Singapore
- Jon Kerry
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Programme, Radcliffe Department of Medicine, University of Oxford
- Touati Benoukraf
- Cancer Science Institute of Singapore, National University of Singapore
- Deepak Bararia
- Cancer Science Institute of Singapore, National University of Singapore
- Feng Li
- Cancer Science Institute of Singapore, National University of Singapore
- Erica Ballabio
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Programme, Radcliffe Department of Medicine, University of Oxford
- Marta Tapia
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Programme, Radcliffe Department of Medicine, University of Oxford
- Aniruddha J. Deshpande
- Sanford Burnham Prebys Medical Discovery Institute
- Robert S. Welner
- Division of Hematology/Oncology, The University of Alabama at Birmingham, Comprehensive Cancer Center
- Ruud Delwel
- Department of Hematology, Erasmus University Medical Center
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Thomas A. Milne
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Programme, Radcliffe Department of Medicine, University of Oxford
- Reshma Taneja
- Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
- Daniel G. Tenen
- Cancer Science Institute of Singapore, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-018-03854-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves SHARP1 as a critical target.
