Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Shangfeng Wang; Yong Fan; Dandan Li; Caixia Sun; Zuhai Lei; Lingfei Lu; Ting Wang; Fan Zhang

doi:10.1038/s41467-019-09043-x

Nature Communications (Mar 2019)

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Shangfeng Wang,
Yong Fan,
Dandan Li,
Caixia Sun,
Zuhai Lei,
Lingfei Lu,
Ting Wang,
Fan Zhang

Affiliations

Shangfeng Wang: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Yong Fan: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Dandan Li: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Caixia Sun: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Zuhai Lei: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Lingfei Lu: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Ting Wang: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
Fan Zhang: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University

DOI: https://doi.org/10.1038/s41467-019-09043-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Fluorophores operating in the second near-infrared window suffer from solvatochromism-caused fluorescence quenching in biological aqueous solution. Here, the authors synthesized a series of pH-responsive pentamethine cyanine fluorophores that afford stable absorption/emission beyond 1000 nm.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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