Influence of smoking habits on acute outcome of revascularization of chronic total occlusion

Abstract

Objective: Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) remains a major challenge in interventional cardiology. The exact toxic components of cigarette smoke and the mechanisms involved in smoking-related cardiovascular dysfunction are largely unknown, but it increases inflammation, thrombosis, and oxidation of low-density lipoprotein cholesterol. There is only insignificant knowledge reported in the literature about the influence of smoking habits on acute outcome in CTO PCI. Methods: Between 2012 and 2017, a total of 559 patients were included in the study. The patients all underwent PCI for at least 1 CTO. Antegrade and retrograde CTO techniques were applied. The Shapiro-Wilk test was used to test for normality of distribution. Continuous variables were tested for differences with the Kruskal–Wallis test or the Mann–Whitney U test, as appropriate. Categorical variables were tested using Fisher's exact test. Results: Non-smokers were older than smoking patients (65.3+-10.3 years vs. 58.3+-9.2 years; p<0.001). The mean age of the cohort was 62.1 years (+-10.5). Smokers were more often male (85.7% vs. 79.7%; p=0.074), suffered from longer lesion length (36.1+-17.5 mm vs. 39.1+-17.2 mm; p=0.023) and therefore needed longer stents (64.2+-26.5 mm vs. 69.0+-28.0 mm; p=0.084). The success rate was comparable for smokers and non-smokers. In-hospital procedural complications were rare and demonstrated no statistically significant difference. Conclusion: The results of this retrospective study revealed no significant association between smoking and acute outcome in CTO PCI. Smokers did, however, have longer lesions and needed longer stents.

Keywords

• chronic total occlusion
• percutaneous coronary intervention; smoking habits.