Nature Communications (Mar 2021)

The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5

  • Lihi Radomir,
  • Matthias P. Kramer,
  • Michal Perpinial,
  • Nofar Schottlender,
  • Stav Rabani,
  • Keren David,
  • Anna Wiener,
  • Hadas Lewinsky,
  • Shirly Becker-Herman,
  • Rina Aharoni,
  • Ron Milo,
  • Claudia Mauri,
  • Idit Shachar

DOI
https://doi.org/10.1038/s41467-021-22230-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10+ Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmunity, thereby hinting SLAMF5 as a potential target for immunotherapy.