Diabetes, Metabolic Syndrome and Obesity (Jul 2024)
The Plasma Levels of Protein Adiponectin (AdipoQ) and Meteorin-Like (Metrnl) in Newly Diagnosed Type 2 Diabetes Mellitus
Abstract
Lan Dam Thi Phuong,1,2 Thinh Tran Huy,1 Thuan Huynh Quang2 1Biochemistry Department, Hanoi Medical University, Hanoi, Vietnam; 2Department of Biochemistry, 103 Military Hospital, Vietnam Military Medical University, Hanoi, VietnamCorrespondence: Thuan Huynh Quang, Department of Biochemistry, 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam, Tel +84 904175342, Email [email protected]: This study aimed to measure the concentrations of the Adiponectin and Meteorin – Like (Metrnl) in newly diagnosed type 2 diabetes patients.Patients and Methods: A comparative cross-sectional study contained two groups: Group 1 (86 newly diagnosed diabetes mellitus type 2 patients) and group 2 (71 healthy persons). The plasma concentrations of Adiponectin and Metrnl were measured by Enzyme Link Immunosorbent Assay (ELISA).Results: The plasma level of Adiponectin of the newly diagnosed diabetes mellitus type 2 group and the healthy group were 1219.82 ng/mL ( 1132.43– 2772.50) and 1187.25 ng/mL ( 1160.66– 3807.50) respectively. The plasma level of Metrnl of two groups were 757.60 pg/mL ( 564.15– 994.00) and 697.60 pg/mL ( 538.50– 986.10) respectively. There were no significant difference between two groups. Metrnl had no correlation with glucose, HbA1c, lipid profile, BMI. Adiponectin had correlation with Metrnl and HDL-cholesterol. Adiponectin had no correlation to glucose, HbA1c, LDL-cholesterol, total cholesterol, triglyceride, BMI. People with the lower Adiponectin concentration had the higher risk of diabetes (OR=6.52; 95% CI: 2.43 − 17.55).Conclusion: Adiponectin and Metrnl were not significantly different in newly diagnosed type 2 diabetes and healthy people. The lower concentration of Adiponectin might increase the risk of type 2 diabetes.Keywords: adipokine, insulin resistance, subfatin, adipo tissuse, adipocyte - complement related protein of 30kDa, ACRP30
