DUbbing Language-therapy CINEma-based in Aphasia post-Stroke (DULCINEA): study protocol for a randomized crossover pilot trial
Blanca Fuentes,
Lydia de la Fuente-Gómez,
Cristian Sempere-Iborra,
Celia Delgado-Fernández,
Aida Tarifa-Rodríguez,
María Alonso de Leciñana,
Elena de Celis-Ruiz,
Raquel Gutiérrez-Zúñiga,
José López-Tàppero,
Marta Martín Alonso,
Sylvia Pastor-Yborra,
Ricardo Rigual,
Gerardo Ruiz-Ares,
Jorge Rodríguez-Pardo,
Javier Virués-Ortega,
Alberto M. Borobia,
Paloma Blanco,
Nereida Bueno-Guerra
Affiliations
Blanca Fuentes
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Lydia de la Fuente-Gómez
Neurosciences Area, IdiPAZ Institute for Health Research
Cristian Sempere-Iborra
Neurosciences Area, IdiPAZ Institute for Health Research
Celia Delgado-Fernández
Neurosciences Area, IdiPAZ Institute for Health Research
Aida Tarifa-Rodríguez
Department of Psychology, Universidad Autónoma de Madrid
María Alonso de Leciñana
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Elena de Celis-Ruiz
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Raquel Gutiérrez-Zúñiga
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
José López-Tàppero
Speech and Language Unit, Department of Rehabilitation, La Paz University Hospital and Universidad Complutense de Madrid
Marta Martín Alonso
Speech and Language Unit, Department of Rehabilitation, La Paz University Hospital
Sylvia Pastor-Yborra
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Ricardo Rigual
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Gerardo Ruiz-Ares
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Jorge Rodríguez-Pardo
Department of Neurology and Stroke Center, La Paz University Hospital, Department of Medicine, Neurosciences Unit, Universidad Autónoma de Madrid, IdiPAZ Institute for Health Research
Javier Virués-Ortega
Department of Psychology, Universidad Autónoma de Madrid
Alberto M. Borobia
Clinical Trials Unit, Department of Clinical Pharmacology, La Paz University Hospital, IdiPAZ Institute for Health Research
Paloma Blanco
Asociación Afasia Activa
Nereida Bueno-Guerra
Department of Psychology, Universidad Pontificia Comillas
Abstract Background Communication is one of the most important predictors of social reintegration after stroke. Approximately 15–42% of stroke survivors experience post-stroke aphasia. Helping people recover from aphasia is one of the research priorities after a stroke. Our aim is to develop and validate a new therapy integrating dubbing techniques to improve functional communication. Methods The research project is structured as three work packages (WP). WP1: development of the dubbed language cinema-based therapy: Two research assistants (a speech therapist and a dubbing actor) will select the clips, mute specific words/sentences in progressive speech difficulty, and guide patients to dub them across sessions. Words to be dubbed will be those considered to be functionally meaningful by a representative sample of aphasic patients and relatives through an online survey. WP2: a randomized, crossover, interventional pilot study with the inclusion of 54 patients with post-stroke non-fluent aphasia. Patients will be treated individually in 40-min sessions twice per week for 8 weeks. Primary outcomes will be significant pre/post differences in scores in the Communicative Activity Log (CAL) questionnaire and Boston Diagnostic Aphasia Examination (BDAE) administered by a psychologist blinded to the patients’ clinical characteristics. Secondary outcomes: General Health Questionnaire (GHQ)-12, Stroke Aphasia Quality of Life Scale (SAQOL-39), Western Aphasia Battery Revised (WAB-R), and the Stroke Aphasic Depression Questionnaire (SADQ10). WP3: educational activities and dissemination of results. WP3 includes educational activities to improve public knowledge of aphasia and dissemination of the results, with the participation of the Spanish patients’ association Afasia Activa. Discussion This pilot clinical trial will explore the efficacy of a new therapeutic tool based on dubbing techniques and computer technology to improve functional communication of patients suffering from post-stroke aphasia with the use of standardized test assessment. Trial registration ClinicalTrials.gov NCT04289493 . Registered on 28 February 2020.
