Synthesis, structure, and antimicrobial activity of aminated 5-chloro-6-nitrobenzofurazan with substituted anilines

Abstract

A simple and efficient procedure for synthesis of nucleophilc aromatic substitution products in benzofurazan cycle on the basis of reactions of substituted anilines with 5-chloro-6-nitrobenzofurazan has been elaborated. The obtained products have a broad spectrum of antibacterial and antimycotic activity. The structure of compounds has been confirmed by IR-, NMR-spectroscopy and also by single-crystal X-ray analysis. Thermal stability of the products has been studied by the combined method of thermogravimetry and differential scanning calorimetry (TG-DSC).

Keywords

• substituted anilines
• 5-chloro-6-nitrobenzofurazan
• nucleophilc aromatic substitution
• synthesis
• structure
• heterocyclic compounds