Haematologica (Jan 2007)

Recombinant granulocyte-colony stimulating factor as treatment for poor prognosis oligoblastic acute myeloid leukemia in elderly patients

  • Anna Maria Pelizzari,
  • Monica Drera,
  • Mariella D’Adda,
  • Marco Ungari,
  • Daniela Marocolo,
  • Fabio Facchetti,
  • Daniela Bellotti,
  • Sergio Barlati,
  • Giuseppe Rossi

DOI
https://doi.org/10.3324/haematol.10185
Journal volume & issue
Vol. 92, no. 1

Abstract

Read online

Twenty-five elderly patients with oligoblastic acute myeloid leukemia (AML) received subcutaneous granulocyte colony-stimulating factor (filgrastim) in addition to supportive care. Ninety-two percent of the patients had multilineage dysplasia, 17% hypoplasia, and 48% a high-risk karyotype. During filgrastim treatment neutrophil and platelet counts increased significantly (p