Case Reports in Oncology (Jun 2021)

Challenge and Outcome for the Prostate Squamous Cell Carcinoma Which Developed 8 Years after Low-Dose-Rate Brachytherapy Approached by a Combined Multimodal Treatment with High-Dose-Rate Interstitial Brachytherapy, External Beam Radiation Therapy, and Chemotherapy

  • Toru Matsugasumi,
  • Koji Masui,
  • Kaori Yamada,
  • Sho Watanabe,
  • Koji Okihara,
  • Nana Kozawa,
  • Yasuhiro Yamada,
  • Hideya Yamazaki,
  • Kei Yamada,
  • Osamu Ukimura

DOI
https://doi.org/10.1159/000516034
Journal volume & issue
Vol. 14, no. 2
pp. 854 – 860

Abstract

Read online

Prostate squamous cell carcinoma (pSCC) rarely develops as a secondary cancer after treatment with low-dose-rate brachytherapy (LDR-BT). There is no established effective treatment for the disease condition. Herein, we present a 78-year-old man who developed pSCC 8 years after LDR-BT. He was subsequently selected to receive a combined multimodal treatment with high-dose-rate interstitial brachytherapy (HDR-ISBT), external beam radiation therapy, and chemotherapy for his pSCC. Eleven months later, he displayed no biochemical failure nor clinical radiographic recurrence. However, MRI detected a newly developed prostatic-rectal fistula (grade 4), and a colostomy was performed to relieve pain and inflammation. To our knowledge, this is the first report to perform a combined multimodal treatment with HDR-ISBT for pSCC suspected as a secondary cancer due to LDR-BT.

Keywords