Sampling of structure and sequence space of small protein folds

Thomas W. Linsky; Kyle Noble; Autumn R. Tobin; Rachel Crow; Lauren Carter; Jeffrey L. Urbauer; David Baker; Eva-Maria Strauch

doi:10.1038/s41467-022-34937-8

Nature Communications (Nov 2022)

Sampling of structure and sequence space of small protein folds

Thomas W. Linsky,
Kyle Noble,
Autumn R. Tobin,
Rachel Crow,
Lauren Carter,
Jeffrey L. Urbauer,
David Baker,
Eva-Maria Strauch

Affiliations

Thomas W. Linsky: Department of Biochemistry, University of Washington
Kyle Noble: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
Autumn R. Tobin: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
Rachel Crow: Department of Microbiology, University of Washington
Lauren Carter: Institute for Protein Design, University of Washington
Jeffrey L. Urbauer: Department of Chemistry, University of Georgia
David Baker: Department of Biochemistry, University of Washington
Eva-Maria Strauch: Department of Pharmaceutical and Biomedical Sciences, University of Georgia

DOI: https://doi.org/10.1038/s41467-022-34937-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

In this work the authors provide a computational workflow for the parallel, from scratch, design of proteins to rapidly explore the shape diversity of protein folds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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