Cardiovascular Diabetology (Jul 2008)

Interaction between <it>Calpain 5, Peroxisome proliferator-activated receptor-gamma </it>and <it>Peroxisome proliferator-activated receptor-delta </it>genes: a polygenic approach to obesity

  • Ruiz Agustín,
  • Serrano-Hernando Javier,
  • González-Pérez Antonio,
  • Martínez-Larrad María T,
  • Manzano Luis,
  • Morón Francisco J,
  • Grilo Antonio,
  • Sáez María E,
  • Ramírez-Lorca Reposo,
  • Serrano-Ríos Manuel

DOI
https://doi.org/10.1186/1475-2840-7-23
Journal volume & issue
Vol. 7, no. 1
p. 23

Abstract

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Abstract Context Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Objective To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Design Cross-sectional, genetic association study and gene-gene interaction analysis. Subjects The study sample comprise 1953 individuals, 725 obese (defined as body mass index ≥ 30) and 1228 non obese subjects. Results In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04–1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%. Conclusion Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.