Nature Communications (Sep 2022)
Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process
- Xindi Gao,
- Yi Fu,
- Shengyi Sun,
- Tingyi Gu,
- Yanjian Li,
- Tianshu Sun,
- Hailong Li,
- Wei Du,
- Chenhao Suo,
- Chao Li,
- Yiru Gao,
- Yang Meng,
- Yue Ni,
- Sheng Yang,
- Tian Lan,
- Sixiang Sai,
- Jiayi Li,
- Kun Yu,
- Ping Wang,
- Chen Ding
Affiliations
- Xindi Gao
- College of Life and Health Sciences, Northeastern University
- Yi Fu
- College of Life and Health Sciences, Northeastern University
- Shengyi Sun
- College of Life and Health Sciences, Northeastern University
- Tingyi Gu
- College of Life and Health Sciences, Northeastern University
- Yanjian Li
- College of Life and Health Sciences, Northeastern University
- Tianshu Sun
- Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases
- Hailong Li
- NHC Key Laboratory of AIDS Immunology, National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University
- Wei Du
- College of Life and Health Sciences, Northeastern University
- Chenhao Suo
- College of Life and Health Sciences, Northeastern University
- Chao Li
- College of Life and Health Sciences, Northeastern University
- Yiru Gao
- College of Life and Health Sciences, Northeastern University
- Yang Meng
- College of Life and Health Sciences, Northeastern University
- Yue Ni
- College of Life and Health Sciences, Northeastern University
- Sheng Yang
- College of Life and Health Sciences, Northeastern University
- Tian Lan
- College of Life and Health Sciences, Northeastern University
- Sixiang Sai
- School of Medicine, Binzhou Medical University
- Jiayi Li
- Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Lund University, BMC A10
- Kun Yu
- College of Medicine and Biological Information Engineering, Northeastern University
- Ping Wang
- Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center
- Chen Ding
- College of Life and Health Sciences, Northeastern University
- DOI
- https://doi.org/10.1038/s41467-022-33168-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Mitochondrial quality control prevents accumulation of intramitochondrial reactive oxygen species (mtROS), thus protecting cells against DNA damage. Here, Gao et al. show that an atypical heat shock factor responds to intramitochondrial stresses and regulates mtROS homeostasis in the pathogenic fungus Cryptococcus neoformans.
