Nature Communications (Nov 2021)

Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat

  • Fenfen Li,
  • Jia Jing,
  • Miranda Movahed,
  • Xin Cui,
  • Qiang Cao,
  • Rui Wu,
  • Ziyue Chen,
  • Liqing Yu,
  • Yi Pan,
  • Huidong Shi,
  • Hang Shi,
  • Bingzhong Xue

DOI
https://doi.org/10.1038/s41467-021-27141-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 22

Abstract

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Brown adipocytes contribute to energy balance, and adipocyte development and brown adipocyte thermogenesis are in part regulated by epigenetic modifications. Here the authors report that the histone demethylase Utx maintains brown adipocyte identity via demethylation of PRDM16, which in turn represses myogenic remodelling via DNMT1-mediated Myod1 promoter hypermethylation in mice.