Type III collagen disorders: A case report and review of literature

Indian Journal of Pathology and Microbiology. 2016;59(1):75-77 DOI 10.4103/0377-4929.174822


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Journal Title: Indian Journal of Pathology and Microbiology

ISSN: 0377-4929 (Print); 0974-5130 (Online)

Publisher: Medknow Publications

LCC Subject Category: Medicine: Pathology | Science: Microbiology

Country of publisher: India



A Anitha
Mahesha Vankalakunti
Vishwanath Siddini
Kishore Babu
Ravishankar Bonu
Sudarshan Ballal



Abstract | Full Text

Collagen type III is a normal component of interstitium and blood vessels. Collagenofibrotic glomerulopathy (CG) and nail patella syndrome (NPS) are the diseases of abnormal type III collagen deposition. In spite of these curved frayed structures with a periodicity of 45-60 nm are deposited in subendothelium and mesangium in CG, they are found only in the basement membrane in NPS. The clinical features of CG are confined to the kidney, NPS has associated extra-renal manifestations. Electron microscopy is essential to make the renal diagnosis in both these rare diseases. Both the entities considered to be systemic diseases evidence to suggest similar deposition in other organs, understanding etiopathogenesis and disease progression await research.