Nature Communications (Mar 2021)
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
- Lars Custers,
- Eleonora Khabirova,
- Tim H. H. Coorens,
- Thomas R. W. Oliver,
- Camilla Calandrini,
- Matthew D. Young,
- Felipe A. Vieira Braga,
- Peter Ellis,
- Lira Mamanova,
- Heidi Segers,
- Arie Maat,
- Marcel Kool,
- Eelco W. Hoving,
- Marry M. van den Heuvel-Eibrink,
- James Nicholson,
- Karin Straathof,
- Liz Hook,
- Ronald R. de Krijger,
- Claire Trayers,
- Kieren Allinson,
- Sam Behjati,
- Jarno Drost
Affiliations
- Lars Custers
- Princess Máxima Center for Pediatric Oncology
- Eleonora Khabirova
- Wellcome Sanger Institute
- Tim H. H. Coorens
- Wellcome Sanger Institute
- Thomas R. W. Oliver
- Wellcome Sanger Institute
- Camilla Calandrini
- Princess Máxima Center for Pediatric Oncology
- Matthew D. Young
- Wellcome Sanger Institute
- Felipe A. Vieira Braga
- Amsterdam UMC, University of Amsterdam
- Peter Ellis
- Wellcome Sanger Institute
- Lira Mamanova
- Wellcome Sanger Institute
- Heidi Segers
- Department of Pediatric Hemato-Oncology, University Hospital Leuven
- Arie Maat
- Princess Máxima Center for Pediatric Oncology
- Marcel Kool
- Princess Máxima Center for Pediatric Oncology
- Eelco W. Hoving
- Princess Máxima Center for Pediatric Oncology
- Marry M. van den Heuvel-Eibrink
- Princess Máxima Center for Pediatric Oncology
- James Nicholson
- Cambridge University Hospitals NHS Foundation Trust
- Karin Straathof
- UCL Great Ormond Street Hospital Institute of Child Health Biomedical Research Centre
- Liz Hook
- Cambridge University Hospitals NHS Foundation Trust
- Ronald R. de Krijger
- Princess Máxima Center for Pediatric Oncology
- Claire Trayers
- Cambridge University Hospitals NHS Foundation Trust
- Kieren Allinson
- Cambridge University Hospitals NHS Foundation Trust
- Sam Behjati
- Wellcome Sanger Institute
- Jarno Drost
- Princess Máxima Center for Pediatric Oncology
- DOI
- https://doi.org/10.1038/s41467-021-21675-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.
