One Pot Synthesis of CuO-CuFe2O4@rGO Nanostructure with Synergistic Effect for Efficient Electrochemical Sensing Application of Paracetamol

Abstract

In the present study, the facile and synergistic approach for electrochemical sensing of paracetamol (PA) drug was demonstrated by hydrothermally synthesized copper oxide-copper ferrite nanohybrid composite supported on reduced graphene oxide (CuO-CuFe _2 O _4 @rGO) glassy carbon electrode. The surface texture and structural information of the electrode material were examined by FE-SEM, HR-TEM, and X-ray diffraction techniques, whereas the electrochemical sensing application of paracetamol oxidation was investigated by amperometric method. The average crystallite size of CuO-CuFe _2 O _4 was calculated from XRD data and found to be 35.45 nm. The fabricated sensor exhibited a higher sensitivity of 970.26 μ A.mM ^−1 .cm ^−2 along with a lower limit of detection (LOD) and limit of quantification (LOQ) of 7.0 μ M and 25 μ M, respectively, with a linear dynamic range of 10–1200 μ M. Furthermore, the CuO-CuFe _2 O _4 @rGO modified sensor showed excellent anti-interferents ability, long-term stability and reproducibility towards electro-oxidation of paracetamol drug. Moreover, it can be efficiently applied for the analysis of paracetamol in biological samples. Finally, the synthesized nanocomposite material was validated to be a competent electrocatalyst for electrochemical sensing application of paracetamol.

Keywords

• electrochemical sensor
• voltametry
• synergistic effect
• paracetamol
• nanocomposites
• sensor.