Nature Communications (Nov 2018)

Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels

  • Erik W. Hartwick,
  • David A. Costantino,
  • Andrea MacFadden,
  • Jay C. Nix,
  • Siqi Tian,
  • Rhiju Das,
  • Jeffrey S. Kieft

DOI
https://doi.org/10.1038/s41467-018-07542-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Complex RNA three-dimensional structures undergo functionally important programmed conformational changes. Here, the authors report how two structurally and functionally coupled RNA domains within a viral 3′-UTR sense the ribosome through conformational changes and respond by modulating translation.