Autocrine Transforming  Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein

Fariba  Navid; John J. Letterio; Choh L. Yeung; Michiel  Pegtel; Lee J. Helman

doi:10.1080/13577140020008057

Sarcoma (Jan 2000)

Autocrine Transforming Growth Factor-β Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein

Fariba Navid,
John J. Letterio,
Choh L. Yeung,
Michiel Pegtel,
Lee J. Helman

Affiliations

Fariba Navid: Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USA
John J. Letterio: Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USA
Choh L. Yeung: Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USA
Michiel Pegtel: Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USA
Lee J. Helman: Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USA

DOI: https://doi.org/10.1080/13577140020008057
Journal volume & issue: Vol. 4, no. 3
pp. 93 – 102

Abstract

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Purpose. Production of active transforming growth factor-β (TGF-β ) by human osteosarcoma may contribute to malignant progression through mechanisms that include induction of angiogenesis, immune suppression and autocrine growth stimulation of tumor cell growth.To study events associated with induction of cell proliferation by TGF-β , we have evaluated the TGF-β pathway in two murine osteosarcoma cell lines, K7 and K12.

Published in Sarcoma

ISSN: 1357-714X (Print); 1369-1643 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.hindawi.com/journals/sarcoma/

About the journal