Real-life outcomes of unselected acute promyelocytic leukemia patients: a single-center 14-year experience

Abstract

Background. After the inclusion of all-trans retinoic acid (ATRA) into the treatment of Acute Promyelocytic leukemia (APL), a notable improvement concerning the survival rates of patients with APL has been observed. However, the population-based studies demonstrated that there was no marked improvement in the survival of patients after the 2000s. We aim to describe the clinical response and prognosis of adult patients diagnosed with APL and examine the change in these outcomes by the time period of diagnosis.

Keywords

• acute promyelocytic leukemia
• early death
• overall survival
• real-life outcomes
• predictors