P106 RELATIONSHIP BETWEEN CENTRAL PULSE PRESSURE AND URINARY SODIUM EXCRETION IN A POPULATION-BASED STUDY IN SALVADOR, BRAZIL, PRELIMINARY RESULTS

Abstract

Introduction: Central Pressure (PC) has shown to be more reliable in cardiovascular (CV) mortality (1); Salt intake and excretion seems to lead to an increase in this pulsatile component of the arterial flow (2, 3). C entral Pulse Pressure (PPc) data is very few. Methods: A population-based cross-sectional study representative of a poor and mixed-race neighborhood of Salvador-B A, Brazil, distributed in 12 census tracts according to the Brazilian Institute of Geography and Statistics. The overall sample is randomized in adults from the assigned area, from December 2016 to May 2018 comprise 110 people. Individual and household records are filled out. The central pressure, measured in the radial artery, obtained through aplanation tonometry, using the SphygmoCor® (XCEL, AtCor Medical, Sydney, Australia (2), with operation index ≥85%. PP c measured by systolic central pressure minus diastolic central pressure. 24-hour urine samples were collected. Urinary sodium (US) measured by the selective ion electrode, ADVIA1800® (SiemensHealthcare Japan/Canada). The committee for research on human subjects of the FTC approved the protocol (No1827621). Median, interquartile range, Spearman’s linear correlation coefficient between PPc and sodium stratified by sex, using STATA v.12 software for data base management and statistical analysis. The level of statistical significance was set at 5%. Results: 71,8% female, mean age 49,7 ± 16y. Median excretion rate of sodium was, in male,133,2 ± 82 mEq/l (In general 126,4 ± 84). In male was a significance negative correlation (r = −0,43;p = 0,01)between PPC and US excretion. Conclusion: There was a correlation between the values of PPc and UR in men (fig.1). These results need future best understanding.