Nature Communications (Oct 2020)
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
- Irene Rodriguez-Hernandez,
- Oscar Maiques,
- Leonie Kohlhammer,
- Gaia Cantelli,
- Anna Perdrix-Rosell,
- Joanne Monger,
- Bruce Fanshawe,
- Victoria L. Bridgeman,
- Sophia N. Karagiannis,
- Rosa M. Penin,
- Joaquim Marcolval,
- Rosa M. Marti,
- Xavier Matias-Guiu,
- Gilbert O. Fruhwirth,
- Jose L. Orgaz,
- Ilaria Malanchi,
- Victoria Sanz-Moreno
Affiliations
- Irene Rodriguez-Hernandez
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Oscar Maiques
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Leonie Kohlhammer
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Gaia Cantelli
- Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London
- Anna Perdrix-Rosell
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Joanne Monger
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Bruce Fanshawe
- Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London
- Victoria L. Bridgeman
- Tumour Host Interaction Laboratory, The Francis Crick Institute
- Sophia N. Karagiannis
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London and NIHR Biomedical Research Centre at Guy’s and St Thomas’ Hospitals and King’s College London
- Rosa M. Penin
- Department of Pathology, Hospital Universitari de Bellvitge, IDIBELL, l’Hospitalet de Llobregat
- Joaquim Marcolval
- Department of Dermatology, Hospital Universitari de Bellvitge, IDIBELL, l’Hospitalet de Llobregat
- Rosa M. Marti
- Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRB LleidaI, CIBERONC
- Xavier Matias-Guiu
- Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRB Lleida, CIBERONC
- Gilbert O. Fruhwirth
- Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, Kings’ College London
- Jose L. Orgaz
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- Ilaria Malanchi
- Tumour Host Interaction Laboratory, The Francis Crick Institute
- Victoria Sanz-Moreno
- Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square
- DOI
- https://doi.org/10.1038/s41467-020-18951-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
