Study on electrochemical sensor for sunitinib cancer medicine based on metal-organic frameworks and carbon nanotubes nanocomposite

Abstract

The determination of sunitinib (STB) as a significant anticancer drug is very important. In the present research, a novel and effective electrochemical sensing device for STB was manufactured using the modification of a glassy carbon electrode (GCE) with the 2D layered metal-organic framework-carbon nanotubes (2DMOF-CNTs) nanocomposite. The electro-oxidation of STB exhibited a notable enhancement in the anodic current at +0.70 V, which may be due to the catalytic character of the 2DMOF-CNTs modifier. The key experimental parameters affecting the efficiency of the STB sensor including amount of 2DMOF-CNTs and solution pH of were evaluated and optimized. The 2DMOF-CNTs/GCE demonstrated a linear response in detecting STB, covering a range from 0.02 µM to 30 µM. In addition, the established sensor showed a good detection limit of 5 nM based on signal-to-noise ratio of 3. The successful evaluation of the practical implementation of the 2DMOF-CNTs/GCE for STB detection in serum samples as the real sample was accomplished. The novel electrochemical device possesses several remarkable properties, such as broad linear range, low limit of detection, quick analysis time, high selectivity, and convenient operation.

Keywords

• Chemotherapy medication
• Sunitinib
• Electrochemical sensor
• Anticancer drug
• 2D layered metal-organic framework