Molecules (Jun 2023)

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

  • Nikolay Petkov,
  • Ivayla Pantcheva,
  • Anela Ivanova,
  • Radostina Stoyanova,
  • Rositsa Kukeva,
  • Radostina Alexandrova,
  • Abedullkader Abudalleh,
  • Petar Dorkov

DOI
https://doi.org/10.3390/molecules28124676
Journal volume & issue
Vol. 28, no. 12
p. 4676

Abstract

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The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M4+ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the coordination processes between MonH/SalH and ions of Ce4+. (1) Methods: Novel monensinate and salinomycinate cerium(IV)-based complexes were synthesized and structurally characterized by elemental analysis, a plethora of physicochemical methods, density functional theory, molecular dynamics, and biological assays. (2) Results: The formation of coordination species of a general composition [CeL2(OH)2] and [CeL(NO3)2(OH)], depending on reaction conditions, was proven both experimentally and theoretically. The metal(IV) complexes [CeL(NO3)2(OH)] possess promising cytotoxic activity against the human tumor uterine cervix (HeLa) cell line, being highly selective (non-tumor embryo Lep-3 vs. HeLa) compared to cisplatin, oxaliplatin, and epirubicin.

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