Clinical observation of POEMS-syndrome: difficulties of diagnosis and treatment

Abstract

Abstract:POEMS syndrome is a rare systemic disease that manifests with the following main symptoms: polyneuropathy, organomegaly, endocrinopathy, paraproteinemia, skin changes. A clinical case of POEMS syndrome in a 42-year-old patient is presented. The diagnosis was verified after the appearance and increase of extraneural symptoms, such as severe edema, respiratory failure, endocrinopathy, hepatosplenomegaly, lymphadenopathy. Additional patient examinations have been done and typical for this disease paraproteinemia has been identified. A course of specific therapy was undertaken in the hematology department, a positive effect was noted. Due to multisystem organ damage, there may be a variety of onset of the disease, which makes it difficult to correctly diagnose and prescribe appropriate therapy.

Keywords

• рoems-синдром
• парапротеинемия
• полинейропатия
• органомегалия