mSystems (Jun 2021)

Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation

  • Huiping Liao,
  • Yuchao Zhang,
  • Wei Guo,
  • Xi Wang,
  • Hailong Wang,
  • Haocheng Ye,
  • Kai Wu,
  • Yu-Hang Zhang,
  • Lingyun Guo,
  • Yufei Zhu,
  • Yongli Guo,
  • Landian Hu,
  • Gang Liu,
  • Xiangyin Kong

DOI
https://doi.org/10.1128/mSystems.00049-21
Journal volume & issue
Vol. 6, no. 3

Abstract

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This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets and were correlated with the CRP level in blood and granulocyte percentage in CSF.